Is NAD+ the holy grail of staying youthful?

NAD+: The Cellular Key to Energy and Youthfulness

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme found in every living cell, playing a pivotal role in numerous biological processes. It’s crucial for converting nutrients into cellular energy, maintaining DNA integrity, and supporting cellular defence mechanisms. As we age, our natural NAD+ levels decline—dropping by as much as 50% by middle age. This reduction contributes to decreased energy, slower metabolism, and visible signs of ageing.

How to Boost NAD+ Levels

Traditionally, increasing NAD+ levels required strict dietary restrictions and intense exercise. However, recent research has identified precursors like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) that can effectively elevate NAD+ levels when taken as supplements.

Why Do NAD+ Levels Drop?

As we age, our cells become less efficient at producing NAD+, partly due to a natural decline in the activity of enzymes involved in its synthesis. At the same time, the body’s demand for NAD+ increases to repair age-related cellular damage, creating an imbalance. Environmental stressors such as poor diet, lack of sleep, exposure to toxins, and oxidative stress further accelerate NAD+ depletion, leading to reduced cellular energy and impaired repair mechanisms.

NMN: A Natural Precursor to NAD+

Recent research has spotlighted nicotinamide mononucleotide (NMN) as one of the most promising ways to naturally boost NAD+ levels. NMN is a molecule that occurs naturally in the body and is directly involved in NAD+ biosynthesis.

One clinical study involving 80 healthy middle-aged adults investigated the effects of NMN supplementation over 60 days. Participants received doses of 300 to 900 mg per day. Results showed a significant increase in NAD+ levels and improvements in muscle performance, endurance, and perceived energy levels—without adverse side effects. These findings suggest NMN can play a vital role in promoting vitality and slowing biological ageing.

Sirtuins: The Anti-Ageing Enzymes

NAD+ also activates a group of proteins called sirtuins, which help regulate inflammation, DNA repair, and metabolism. They’re often referred to as “longevity genes” because of their key roles in promoting healthy ageing. However, sirtuins are entirely dependent on NAD+ to function. When NAD+ levels drop, sirtuin activity decreases, accelerating the ageing process.

Rejuvenated’s Solution: Regenerate

Rejuvenated’s Regenerate supplement is expertly formulated with NMN and a blend of potent plant-based sirtuin activators including resveratrol, pterostilbene, fisetin, quercetin phytosome and astragalus. This combination works in harmony to raise NAD+ levels and stimulate sirtuin function, helping to restore energy, protect cells, and promote youthful vitality from within.