This salad is packed with amazing nutrients, vitamins, minerals, antioxidants, proteins and essential fatty acids. The rich variety of vegetables contain many sirtuin boosting compounds to help promote longevity and turn back the biological clock.
In all the talk about being able to turn back our biological age and become more youthful, one ingredient has really turned the nutritional world on fire. That ingredient or molecule is a form of vitamin B3 called nicotinamide mononucleotide or NMN. In initial trials, researchers showed that this form of vitamin B-3 could boost an essential enzyme in our cells. The enzyme, nicotinamide adenine dinucletide (NAD+), is responsible for DNA repair and is in every cell within our body. It is of key importance in our quest to slow down the ageing processes.
What Is NAD+?
NAD+ works with proteins to maintain health and is important for cellular energy.
As a newborn, we have an abundance of this precious enzyme, but levels diminish as we age. As NAD+ is responsible for just about every metabolic process in our cells, it becomes easy to see why it’s decline has a huge impact in the ageing process.
Until now, the only way of boosting levels NAD+ has been through following a very low-calorie restriction diet. However new research indicates that taking an NMN supplement may lead to similar health benefits as those created through calorie reduction1.
Nicotinamide mononucleotide is a precursor for NAD+ which means that if NMN is present in the cells NAD+ will be formed.
Why is NAD+ so important to staying youthful?
This incredible youth boosting molecule has several essential roles that are vital in our wellbeing and preventing age related diseases. It is:
Responsible for DNA Repair
Within every cell in our body
Involved in metabolic processes
Generates adenosine triphosphate (ATP), our cellular energy
Protects cells against stress and damage
However, increasing the level of NAD+ on its own is just part of the story in staying youthful. We need to introduce a family of proteins at this point. This family of proteins is called SIRTUINS. Sirtuins are a group of enzymes which speed up certain chemical reactions within our body, help to provide vital cellular energy by creating new mitochondria. When sirtuins and NAD+ are present together they become more vigorous in their work.
Regenerate by Rejuvenated combines NAD+ boosting NMN with potent sirtuin activating ingredients to work to promote energy levels and cellular health. Discover the benefits yourself – shop now
Sirtuins are a family of 7 proteins that help to regulate the health of our cells. They are a group of enzymes that work to speed up certain chemical reactions in our body. Sirtuins are really quite miraculous in the work they perform to manage the many processes in our cells that are involved in ageing and the diseases associated with the ageing processes. Read on to find out how sirtuins are activated.
What tasks do sirtuins perform in the cells?
The name comes from SIR – Silent Information Regulator
Sirtuins act as protectors for our cells, here’s how:
Respond to damage and fix
Support healthy DNA
Linked to the benefits of fasting and exercise
Work with other genes and respond to damage in the cells
Make enzymes that work to control the epigenome
May reduce the rate that cells divide
This is one of the reasons that they can extend lifespan
These incredible enzymes are essential for healthy cellular metabolism and work to protect us from inflammatory diseases as we age. Sirtuins1help to slow cell ageing through diverse cellular processes, by reducing the rate that cells divide. Why does this matter you might ask? The fact is that cells only have a limited number of times that they can divide. They also work to sustain genome integrity and promote DNA repair.
Studies have linked sirtuins to being able to help to repair DNA damage2 as it’s believed that they protect telomeres, the caps at the end of chromosomes within our DNA. They also help to provide vital cellular energy as they create new mitochondria, the power plant of our cell. Sirtuins also enhance the link between the nucleus and mitochondria so that the mitochondria functions more effectively.
Sirtuins go to work removing old decaying parts of our cells making everything ready for new growth. They are present in every cell and each take on different roles. 3 directly work on the mitochondria (SIRT 3,4 & 5), 3 on the nucleus (SIRT1, 6 & 7) and SIRT2 on the cytoplasm.
While we know the most about SIRT1, the other six sirtuins are now emerging and studies are being carried out to show how they might help to protect us from the major diseases associated with ageing.
How are sirtuins activated?
However, Sirtuins can’t do all this magical work on their own, they need the support of another molecule, NAD+. The intimate relationship between sirtuins and NAD+ is regulated at different levels allowing their coordinating their role in metabolic processes and ageing. NAD+ availability decreases over age, reducing sirtuin activities and affecting the communication between the nucleus and mitochondria at a cellular level and also between the hypothalamus and adipose tissue at a systemic level.
If we can naturally increase NAD+ then we can activate sirtuins to become more vigorous in their work.
Which foods help to stimulate sirtuins?
Functional foods and nutraceuticals hold great promise for health and longevity promotion and prevention of age-related diseases3. Certain foods have natural plant compounds which may be able to increase the level of the sirtuin proteins. Many of them are associated with the foods eaten in Japan and the Mediterranean diet.
Extra virgin olive oil
Which supplements should I take to stimulate sirtuins?
Studies have linked ingredients such as fisetin, quercetin, resveratrol, pterostilbene to enhancing sirtuin activity. These can be found in capsule form to enable easy consumption.
Regenerate by Rejuvenated blends these ingredients with NMN (Nicotinamide Mononucleotide), vitamin B2 and zinc to give a powerful youth promoting capsule.
Studies have revealed that a molecule from grapes has an effect on a group of proteins that are associated with DNA health and longevity. The molecule, resveratrol has an effect on the activity of a group of proteins sirtuins which influence cellular activity including ageing. There are many health benefits of resveratrol which is why we’ve included in our new supplement Regenerate.
Trans-resveratrol is its most active form, it can be combined with other antioxidants to increase its benefits and it is particularly synergistic with pterostilbene, another polyphenol compound
If you’re a red wine lover, you’ll be happy to know that the benefits of a Mediterranean diet are often attributed to the amount of resveratrol within it. The molecule comes from grape skin and contains various cardio protective antioxidants. As scientists discover more about this wonder molecule it is becoming a true hero of the nutritional world.
Resveratrol is gaining much acclaim for its ability to affect the Sirtuins. Sirtuins play many roles across a broad spectrum of biological processes, including those that have a part in age related degenerative diseases. It is similar in composition to another polyphenol, Pterostilbene and when combined together they are especially potent. They specifically help to activate SIRT1, one of the sirtuins within the cell nucleus.
Resveratrol has many other health benefits
Resveratrol Improves Brain flexibility
Activating SIRT1 can help to promote neuronal survival, reducing neurodegeneration to help promote brain health and support cognition and memory. It also helps to increase neurological blood flow.
The Health Benefits of Resveratrol may help to reduce the risk of heart disease
Resveratrol has long been considered to be effective in reducing the risk of atherosclerotic disease, a precursor to heart disease and stroke.
Vision loss is a natural part of ageing, scientists have discovered that resveratrol may help to prevent abnormal growth of blood vessels. Combine your resveratrol supplement with omega 3, vitamin C & E and eat foods rich in beta carotenes.
Increased bone density
Studies have shown that resveratrol may play a part in increased bone density, helping to protect from bone degenerative diseases.
We are excited to announce that our new supplement Cellular Regenerate with NAD+ has been formulated to support normal DNA synthesis and the protection of DNA from oxidative stress.
DNA Protection. Cellular Health. Regenerate
8 Youth Boosting Molecules.
The formula with NAD+. Vitamin B2 and zinc is designed to:
Support healthy cellular ageing
Promote the activation of sirtuins which play a key role in cellular processes
Promote cellular energy and healthy DNA
Reduce tiredness and fatigue
Supports a healthy cardiovascular system
Supports healthy bones
Contributes to cognitive function
How Regenerate supports cellular health
As our bodies age we start to slow down, and energy levels decrease.
One reason for this is the decline of NAD+ (Nicotinamide adenine dinucleotide) a powerful molecule in every cell. It is vital for metabolic processes including cellular energy.
The only way to increase NAD+ levels has been through following a very strict regime of a restrictive low-calorie diet and intense exercise.
Regenerate combines a special form of vitamin B3, Nicotinamide mononucleotide (or NMN) with potent plant molecules to work in synergy to boost NAD+ to youthful levels and activate enzymes (sirtuins) that work to protect DNA and cellular health.
How NMN and NAD+ help to create healthy cells
Taking a supplement containing the molecule NMN stimulates an increased production of NAD+ within our cells. NAD+ then binds to enzymes and causes reactions in the body that have positive outcomes for our health.
One essential role that they play is interacting with sirtuins, a group of cellular proteins that rely on a good supply of NAD+ to perform a multitude of tasks in cellular and mitochondrial health.
Mitochondria are the special structures in our cells; that lose some of their power as we age and this contributes to many age related diseases and fatigue. A study found that increased NAD+ levels could restore mitochondrial function to enable an increase in the formation of energy.
To allow this interaction sirtuins need to be present in abundance; which is why we combined potent plant molecules with NMN in Regenerate
How plant molecules activate sirtuins
Certain foods have natural plant compounds which may be able to increase the level of the sirtuin proteins. Many of them are associated with the foods eaten in Japan and the Mediterranean diet. However, it is virtually impossible to obtain enough of these compounds to have a significant impact from our daily diet.
Regenerate combines plant molecules including, resveratrol, pterostilbene, fisetin, quercetin phytosome and astragalus with NMN to support your body at cellular level.
Pterostilbene is a nutrient from the same family as resveratrol. Scientists are excited about the health benefits of pterostilbene and here’s why. It’s an antioxidant and anti-inflammatory with preventive properties. It has shown to be many times more bioavailable than resveratrol and is easily transported into cells. Pterostilbene has two to four times better cellular uptake than resveratrol and stays present in the body longer before it is eliminated, however it is thought that combining these two ingredients together intensifies their benefits.
The molecule is found naturally in plants particularly berries, grapes and nuts. Although it is most abundant in blueberries, the actual content is miniscule. You’d actually need to eat almost 100 kilos of blueberries daily to see any true benefits from ingredient.
Why you should take pterostilbene?
One of the main reasons that this molecule is gaining so much attention is that it is thought to be a potent sirtuin activating compound. Sirtuins play many roles across a broad spectrum of biological processes, including those that have a part in age related degenerative diseases. Pterostilbene specifically helps to activate SIRT 1 which has influence over DNA proteins. SIRT1 also works in partnership with NAD+ to support DNA repair and its many other cell protecting activities.
It’s early days in the story of this incredible molecule but it is gaining much attention as scientists search for molecules that have a beneficial effect on the genes and how to protect against degenerative diseases.
Pterostilbene is a potent antioxidant and anti-inflammatory agent.
It is a powerful free radical fighter that reduces oxidative stress. There is evidence to show that it may mimic a calorie restriction diet. Such a diet is a practise that is associated with helping to slow down the ageing process.
Studies are in their early days, but they are proving to be very encouraging. One such piece of research showed that it helped to reduce blood pressure in adults1. It did also indicate a slight increase in LDL levels in just pterostilbene alone but when combined with resveratrol there was no evidence of this.
Scientists are performing numerous trials on the molecule as there are indications that it may have anti-cancer effects including inducing:
Aptosis – the removal of potentially harmful cells.
Necrosis – the death of cells in living tissue caused by external influences such as toxins and infection.
Autophagy – an essential process where cells remove unnecessary or damaged components.
Pterostiblene may provide an anti-inflammatory effect with skin by reducing inflammation through autophagy.
An interesting fact is that resveratrol maintains its sirtuin activating properties during the wine making process but pterostilbene loses its ability to stimulate sirtuins during the process.
A Summary of the health benefits of pterostilebene
Pterostilbene works to promote sirtuins in the body, these sirtuins work with another molecule, NAD+ to support DNA Repair and healthy cells. Pterostilbene is more bioavailable than resveratrol in the body but together the two complement each other for enhanced results.
NAD+ levels can be boosted by adding Nicotinamide Mononucleotide as a supplement to your diet. It acts as a precursor for NAD+ which means that if NMN is present in the cells NAD+ will be formed.
Regenerate by Rejuvenated combines these powerful sirtuin activating ingredients with NMN into a potent youth promoting capsules. Discover more »
Fisetin is a very special natural antioxidant, which is part of the polyphenol group of plants, it’s found in some medical plants, vegetables and fruits such as strawberries, apples and persimmon and is particularly good for slowing down the ageing process. It’s most abundant in strawberries, so not only are these possibly the most delicious fruit they also carry the highest amount of this potent ingredient.
This incredible antioxidant works to eliminate senescent (rogue) cells scattered around the body. Studies show that this unique polyphenol may help to reduce markers of senescence and ageing. It was an essential ingredient on our list to include in Regenerate.
What is a Senolytic Cell?
As we age some cells stop dividing and become redundant within the body. They then start to trigger inflammation by releasing inflammatory substances that target neighbouring cells. These are senolytic cells and recent studies have shown that there is a direct relationship between the number of senescent cells in the body and the ageing process including inflammatory diseases.
Apoptosis is a process in which a healthy cells contents are broken down and packaged into small packets of membrane to be removed by immune cells. Once a cell dies it normally self-destructs in a process called autophagy. However, this isn’t the case with senescent cells, and they set to work decimating the cells around them. The good news is that scientists have discovered several compounds, senolytics, that are specifically able to repair the mechanism that allows these cells to self-destruct and prevent them causing damage.
How Fisetin May Help to Stop Cells Becoming Senolytic
Studies have shown that out of 10 compounds tested, Fisetin(1) is the most powerful and natural senolytic for eliminating senescent cells and reactivating autophagy which helps to remove toxic elements that accumulate in cells.
It directly increases the production of other powerful antioxidants(2) including superoxide dismutase, catalase and glutathione, the most powerful anti-inflammatory substance in the body. Fisetin has shown to reduce inflammation
SIRT1 is one of a group of enzyme proteins associated with cellular health. The group known as sirtuins are a family of 7 proteins which work to speed up certain chemical reactions within the body and protect from inflammation. Fisetin has been linked to enhancing the work of SIRT1. SIRT1 plays a key role in cellular health and how we age. Fisetin has also shown to be beneficial in activating SIRT3, SIRT6 and FOXO3a sirtuins.(3)
A study showed that taking fisetin inhibited glucose production.
Fisetin has shown to have several biological benefits including:
Reduction in inflammation. It helps to protect from future inflammation while reducing existing inflammation so that cells can run at full power and repair more effectively.
Protecting bone health
The ability to eliminate senescent cells
It is thought that it may have anti-cancer properties
It helps to make more glutathione, the most anti-inflammatory substance in your body.
Fisetin and bone health
There has been some encouraging work done on the potential of fisetin to combat osteoporosis. Osteoblasts are bone forming cells while osteoclasts break down bone cells, the 2 types of cells are dependent on each other for the production and processes of bone health. in a healthy skeleton these cells work in harmony, however in osteoporosis osteoclasts are more active than osteoblasts causing a net bone loss over time.
Fisetin appears to stimulate the work of osteoblasts while bocks the activity of osteoclasts.
Does fisetin help to protect brain health?
Fisetin can cross the blood brain barrier. Data from preclinical studies suggest that fistein might strengthen the neural connections neural communication – memory and cognitive processes
How to get more fisetin in your diet.
Fisetin is in many fruits and vegetables, here is a list of food sources with the highest concentration, down (shown as micrograms of fisetin per gram of freeze dried food).
Strawberries – 160
Apples – 27
Persimmons – 11
Onions – 5
Grapes – 4
Kiwi – 2
Now you can get the added benefits of fisetin in our ground breaking supplement, Regenerate. Regenerate has been created to help to support cellular health discover more here
Quercetin contains flavonoids, flavonoids are an important group of natural ingredients that occur in abundance in certain plants and foods including fruits, vegetables, tea, cocoa and wine. If you’re wondering what the health benefits of quercetin are, then read on …
Many studies have suggested that flavonoids exhibit biological activities, including anti-allergenic, antiviral, anti-inflammatory and vasodilating actions. However, most interest has been devoted to the antioxidant activity of flavonoids which is due to their ability to reduce free radical formation and to scavenge free radicals.
There are 6000 flavonoids that contribute to the colourful pigments of fruits, herbs, vegetables and medicinal plants.
Quercetin is categorised as a flavanol and is widely distributed throughout the plant kingdom. They are found in a variety of foods including apples, berries, Brassica vegetables, capers, grapes, onions, shallots, tea and tomatoes as well as seeds and nuts. Growing conditions may affect the amount of quercetin within a plant.
Quercetin and its impact on longevity
Quercetin appears to have an effect on certain pathways including the NRF2 pathway1.
This pathway is the system the body turns on when it wants to make its ‘in-house’ antioxidants. When oxidative stress levels get too high, our body automatically activates the pathway.
The NRF2 pathway is associated with stimulating the longevity gene NQ01 (It’s associated with reducing the P-53 gene also called the rumour suppressor gene) which ultimately has a role in increasing the effects of NAD+. NAD+ declines with age and is responsible for just about every metabolic process within our cells.
The health benefit of Quercetins on senescent cells
It’s also a senolytic agent which works to kill off senescent cells (rogue cells) in the body to prevent them from secreting inflammatory substances that cause other cells nearby them to become damaged. As we age the number of senescent cells increase. These rogue cells are thought to be responsible for a host of degenerative diseases, it is thought that eliminating them can increase our overall health.
Quercetin is a potent senolytic agent while at the same time boosting NAD levels. Supplementing with quercetin can play a powerful part in our health and longevity.
How to get more quercetin in your diet.
Quercetin is a pigment that belongs to a group of plant compounds called flavonoids.
Including these foods in your diet will boost your quercetin levels:
Quercetin increases the absorption of resveratrol.
Regenerate by Rejuvenated contains quercetin phytosmome with is 20 times more absorbable than standard quercetin. We have combined it with other potent ingredients and NAD+ boosting NR to work to promote energy levels and cellular health. Discover the benefits yourself – shop now
Astragalus is one of the most potent adaptogen herbs, it helps us to stay youthful, lower stress levels and fight disease.
What is astragalus?
Astragalus has been used in traditional Chinese medicine for centuries. It comes from a bean or legume. Only the roots of the astragalus plants are used and these are harvested when plants are 4-years old. There are over 2000 species of astragalus, however, most astragalus supplements contain Astragalus membranaceus. Currently over 200 compounds have been isolated and identified from the herb and these include polysaccharides, saponins and flavonoids.
How does astragalus help to keep cells young?
Telomeres are caps that protect the end of each strand of DNA, they are like the plastic tips at the end of a shoelace. Telomeres shorten each time a cell divides and act as a clock that signals to cells to age. Eventually the telomeres become so short that the ends of DNA are unprotected, and cells stop functioning or die.
Studies indicate that an enzyme called Telomerase may delay, stop or may even reverse telomere shortening. Several extracts from Astragalus membranceus root have been studied as possible telomerase activators1. Substances within astragalus root (called cycloastragenols and astragalosides) are believed to slow the ageing process by activating telomerase enzyme production. This is the process responsible for telomere regeneration.
Help cells live longer and function as they did when they were younger.
3 components give this plant special qualities for human health:
There are more than 63 flavonoids including isoflavones, isoflavans, pterocarpans, flavonols, flavones, and flavonones. These components are important for cell signalling, their antioxidant properties and support a healthy heart.
These have anti-inflammatory and antiviral properties. Polysaccharides naturally have a high nutritive value and a positive effect on our immune and digestive system and help to remove toxins.
Saponins are plant-based steroids that work to reduce cholesterol levels, improve the immune system and reduce inflammation. Studies indicate that they help to suppress the release of lipase, an enzyme that breaks down dietary fats. As a result, your body will absorb less fat from food.
What are the benefits of astragalus and how is it effective in boosting immunity and health?
Studies continue to reveal the reasons that astragalus has so many health benefits and how it works to protect our cells from disease and oxidation.
Astragalus acts as an anti-inflammatory to help to protect from arthritis to heart disease. The saponins and polysaccharides help to reduce the inflammatory response in many diseases.
Helps to regulate the body’s immune responses.
Boosts heart and cardiovascular health
The flavonoids act as antioxidants and help to protect against hardening of the arteries and the build-up of plaque in the arterial walls.
Helps to fight ageing
Astragalus helps to protect from free radical damage to prevent oxidative stress. It is also reputed to help to protect the telomeres – the caps at the end of our DNA strands.
Helps to protect against diabetes
The combination of saponins, flavonoids, and polysaccharides combine to work to prevent insulin resistance.
How can you include astragalus in your diet?
We love this herb so much that we incorporated it in H3O Night Repair and Regenerate. Just one capsule daily will help to support natural youthfulness and health.
It’s now over a year since the first Coronavirus lockdown began. As we watched from afar, it wasn’t long before the rest of the world followed suit. As the year passed phrases such as ‘lockdown’ and social distancing have become the new norm. Catching up means a zoom call and not meeting up in a coffee shop or going out for a meal together.
The first lockdown was a shock to our system as we came to terms with something never experienced before. There was a hope that it would be at an end once the short, sharp shock was over. Now in our third lockdown there is a feel of being in limbo, a sense of frustration as we wait for our lives to revert to some kind or normality.
As humans we find open ended waiting incredibly difficult to deal with. A team of scientists conducted research into the well-being of a group of individuals in isolation and looked specifically at two coping strategies: flow and mindfulness.
Interestingly it was flow rather than mindfulness, that led to the greater well-being during lockdown. While both practises were beneficial in alleviating anxiety and negative emotions, flow was able to reduce the feelings of loneliness and promote healthy practises.
Mindfulness focuses on the individual’s experiences whereas flow actually reduces our self-awareness. In 1975 American-Hungarian psychologist, Mihaly Csikszentmihalyi, described flow as moments where an individual is “utterly absorbed in what they are doing, paying undivided attention to the task, their awareness merged with their actions.”
He observed that to be in a state of flow, the task must be fundamentally rewarding rather than being influenced by external factors. He wrote;
“The important thing is to enjoy the activity for its own sake, and to know that what matters is not the result, but the control one is acquiring over one’s attention.”
When we give our full attention to an activity that we are passionate about and totally immersed in we can experience a flow state of mind. Tasks should have a purpose such as learning a new craft or playing chess will contribute to a state of flow rather when we are relaxing such as watching the television. You can enter a state of flow by simply gardening or cleaning the house so long as you do it purposefully. Being in a state of flow means that you are doing an activity where you lose the track of time and become fully engrossed.
“Of all the virtues we can learn,” Csikszentmihalyi writes, “no trait is more useful, more essential for survival, and more likely to improve the quality of life than the ability to transform adversity into an enjoyable challenge.”
Have you found something that allows you to create a state of flow?